Hello
In GUIDE there is a possibility disable the download of application and/or parameters until the application has identified that the machine is in a safe state, by using the ServiceTool.DisableWrite and ServiceTool.DisableDownload signals (see attached image).
You will find more information around this in the GUIDE User manual, in the section called "About IEC 61508:2010 Certification" in the very beginning of the manual.
If a safe state is not handled by the application, it is up to the person performing the download to ensure the machine is in a safe state before starting the download.
Best regards
Daniel
PLUS+1® Helpdesk